Preimplantation Genetic Testing (PGT)
The American College of Obstetricians and Gynecologists’ (ACOG) Committee on Genetics developed this opinion paper to draw attention to the present state of PGT technology and its clinical utility. The paper details how the three PGT DNA-based assays are currently used to address various aspects of infertility as well as its utility to eliminate vertical […]
Should We Have Genetic Testing? What is Preimplantation Genetic Testing (PGT)?
Organized in the form of a blog, this short and concise overview by ASRM, with illustrations, provides the general reader and couples considering PGT with an easily digestible introduction to the process. Covering PGT-A, -M, -SR, readers will gain information directly from the American Society of Reproductive Medicine experts on the importance of PGT in […]
Preimplantation Genetic Testing for Monogenic Disorders
In this detailed article published in Genes, the reader can gain insight into the process and advancements in the detection of monogenic disorders and single-gene diseases using PGT-M. It also covers past, present, and future technologies that underpin the usefulness of PGT in the context of familial or de novo genetic diseases. The review stresses […]
Preimplantation Genetic Testing: Where We Are Today
The authors of this review published in the International Journal of Molecular Sciences provide a comprehensive and detailed discussion of the PGT process covering the key steps from embryo biopsy to molecular methods used for embryo analysis to maternal and neonatal outcomes. The level of discussion is geared to practitioners of reproductive medicine but can […]
PGT-A: Guide to Preimplantation Genetic Testing of Embryos in IVF
This informative and clear introduction to PGT-A by Claire O’Neill published in Fertility Space is of value to the general public exploring key aspects of the PGT-A technique. “Everything you need to know as an IVF patient about PGS/PGT-A for genetic testing of your embryos.” This overview addresses the basic questions interested couples may have […]
IVF Outcomes After PGT for Chromosomal Structural Rearrangements Comparing Fluorescence In-situ Hybridization, Microarray Comparative Genomic Hybridization, and Next-Generation Sequencing
Results of this study from the University of Connecticut compared the effectiveness of three approaches for the detection of balanced/normal chromosomal content in embryos from couples who carry chromosomal translocations. Of the three different methods used in the study, the authors suggest that Next Generation Sequencing (NGS) yielded “an improvement in pregnancy outcomes parallel to […]