IVF Outcomes After PGT for Chromosomal Structural Rearrangements Comparing Fluorescence In-situ Hybridization, Microarray Comparative Genomic Hybridization, and Next-Generation Sequencing

Results of this study from the University of Connecticut compared the effectiveness of three approaches for the detection of balanced/normal chromosomal content in embryos from couples who carry chromosomal translocations. Of the three different methods used in the study, the authors suggest that Next Generation Sequencing (NGS) yielded “an improvement in pregnancy outcomes parallel to the advancement in technology and are reassuring for continued use of NGS” for couples where one partner carries a translocation. By using NGS-based PGT-SR methods, these couples have a measured improvement in live-birth rates by avoiding the transfer of chromosomally abnormal embryos.